The Florida Keys are a stunning chain of islands known for their clear waters, vibrant wildlife, and relaxing atmosphere. With so many unique hotels to choose from, visitors can find the perfect spot to unwind and soak in the beauty of the surroundings. From beachfront resorts to cozy inns, the diverse accommodations cater to every traveler’s taste and budget.
Staying at a hotel in the Florida Keys feels like stepping into paradise. You can wake up to the sound of waves gently lapping at the shore and enjoy breathtaking sunrises right from your balcony. Many hotels feature pools, spas, and on-site dining options, making it easy to kick back and enjoy your vacation.
Best Hotels In Florida Keys
1. Southernmost Beach Resort

Welcome to Southernmost Beach Resort, a true paradise in Key West, Florida. You will find multiple pools and direct beach access, perfect for sunbathing or swimming. Enjoy the warm sun while sipping on a cocktail or two at the beach bar.
Located near famous Duval Street, this resort keeps you close to incredible nightlife and dining. Stroll down the vibrant street filled with shops, bars, and restaurants. Here, fun is always just around the corner.
The rooms are cozy, with tropical decor that enhances the laid-back atmosphere. Relax and unwind in luxury while enjoying beautiful sunsets from your balcony. It’s the perfect way to end your day.
Indulge in delicious dining options on-site. Start your morning with a hearty breakfast before heading out for adventure. Every evening brings new opportunities for a romantic dinner or casual cuisine with friends.
Whether you want activity or relaxation, Southernmost Beach Resort offers both in one stunning location. You’ll cherish these memories for years to come.
Address: 1319 Duval St, Key West, FL 33040, United States
2. The Marker Key West Harbor Resort

The Marker Key West Harbor Resort is a gem for those seeking a peaceful getaway. This beautiful waterfront resort is situated in a prime spot, offering fantastic views and easy access to the ocean. Enjoy the gentle breezes as you lounge by the pool.
The resort features stylish accommodations with modern amenities. Each room provides a cozy sanctuary after a day of exploring. You can easily walk to various attractions, letting the excitement of Key West wrap around you.
Whether it’s kayaking or simply enjoying a sunset, the Marker offers it all. Experience the local culture, art, and history just steps away. Relax on the spacious lawn, a perfect setting for evening gatherings.
Dining options at the resort are delightful. Expect a menu filled with fresh and local ingredients. Enjoy a laid-back meal while taking in the breathtaking surroundings.
With its friendly staff and luxurious atmosphere, The Marker Key West Harbor Resort makes every visitor feel special. It’s the ideal place for a well-deserved escape.
Address: 200 William St, Key West, FL 33040, United States
3. Playa Largo Resort & Spa, Autograph Collection

Discover Playa Largo Resort & Spa, a stunning beachfront option in Key Largo. This resort provides luxury accommodations, featuring spacious rooms with high-end finishes and private balconies. Enjoy the soothing sounds of the ocean right outside your door.
The inclusive spa is a highlight, offering rejuvenating treatments that will leave you refreshed. Pamper yourself with massages and beauty therapies, delving into relaxation and serenity.
Dining at Playa Largo is a treat! Taste fresh seafood dishes and tropical cocktails prepared by talented chefs. Enjoy your meals while soaking in picturesque views of the water.
Engage in various activities right at the resort. Water sports abound, ensuring daily adventures on the waves. Explore the beautiful surroundings by paddleboard or kayak, and appreciate the natural beauty of the Florida Keys.
Playa Largo offers the perfect combination of relaxation and adventure. You’ll leave feeling revitalized and eager to return.
Address: 97450 Overseas Hwy, Key Largo, FL 33037, United States
4. Casa Marina Key West, Curio Collection by Hilton
Casa Marina Key West, a historic beachfront property, brings together elegance and nostalgia. This luxurious hotel has been tastefully renovated, ensuring the charm of the original structure remains intact.
Enjoy spacious rooms filled with modern amenities and classic decor that embraces the spirit of Key West. The stunning beach area invites you to unwind, whether it’s swimming or sunbathing.
Delight in exceptional dining options at the resort. Savor fresh seafood dishes packed with flavor, served with a side of beautiful ocean views. Casa Marina is also close to Duval Street’s vibrant nightlife and shops.
Plan a stroll around the property with scenic paths leading through lush landscaping. The atmosphere is upbeat yet serene, making it easy to find a peaceful spot to relax.
Casa Marina offers a memorable experience that embraces the culture of Key West. It’s an ideal escape for couples and families alike!
Address: 1500 Reynolds St, Key West, FL 33040, United States
5. Marquesa Hotel

For a tranquil escape, Marquesa Hotel is a stylish adults-only option in Key West. Located in a charming area, this hotel boasts three inviting pools and a serene atmosphere. You’ll appreciate the peaceful retreat just moments away from bustling attractions.
The accommodations are beautifully designed, prioritizing comfort and charm. Enjoy tasteful decor and cozy settings, perfect for unwinding after a day of exploration.
Indulge in breakfast at their onsite cafe before setting out on daily adventures. The friendly staff provides personalized service that makes you feel right at home.
Located close to historic sites and vibrant nightlife, explore at your own pace. After a day of excitement, retreat to your serene oasis at Marquesa Hotel for a good night’s rest.
Experience luxury and relaxation at Marquesa Hotel. It’s the perfect spot for couples looking for romance in Key West.
Address: 600 Fleming St, Key West, FL 33040, United States
6. The Gardens Hotel

The Gardens Hotel is a delightful boutique hotel in the heart of Key West. With lush gardens and a cozy atmosphere, this charming hotel feels like an oasis. Each room is uniquely decorated, offering a personalized touch for guests.
Wake up to the sweet fragrance of blooming flowers and the gentle sounds of nature. Enjoy a complimentary breakfast surrounded by beautiful gardens. It’s a perfect way to start your day!
Located within walking distance of popular attractions, this hotel makes exploring effortless. Visit local art galleries, shops, and renowned dining spots just steps from your door.
After a day of adventure, return to The Gardens for a refreshing dip in the pool or relax with a drink in the lush courtyard. Evening strolls in the serene gardens are a calming end to your day.
Stay at The Gardens Hotel for a unique experience that beautifully combines nature with Key West charm.
Address: 526 Angela St, Key West, FL 33040, United States
7. Santa Maria Suites Hotel

Santa Maria Suites Hotel is the ultimate destination for guests seeking spacious luxury. Located in Key West, this enchanting hotel features large suites that provide a home-like feel during your stay. Relaxation is key, with oversized rooms and a peaceful atmosphere.
The hotel is just a short walk to the beach, making it convenient for sun-seekers. Enjoy time by the outdoor pool while sipping refreshing drinks and soaking in the sun.
A complimentary beach shuttle ensures you reach the sandy shores effortlessly. After a busy day, retreat back to your suite to rest and recharge for your next adventure.
Dining at nearby restaurants is just as delightful as on-site options. Order in to enjoy a cozy meal at your suite or explore local cuisine in vibrant dining spots around town.
Experience spacious luxury and top-notch service at Santa Maria Suites Hotel—all while being close to all that Key West has to offer.
Address: 1401 Simonton St, Key West, FL 33040, United States
8. Ocean Key Resort & Spa

Ocean Key Resort & Spa is a luxurious escape in Key West. Located right on the waterfront, this resort provides stunning views and easy access to recreational activities. Enjoy a massage or spa treatment while listening to the soothing sounds of the ocean.
The guest rooms offer a perfect blend of comfort and style with tropical decor. You’ll appreciate the modern amenities that enhance your experience. Relax on your patio while watching the sunset over the horizon.
Dining at the resort is a special treat! Enjoy fresh seafood and tropical dishes at the on-site restaurant. Enjoy a beach bonfire as you savor the flavors of key lime pie.
With a vibrant atmosphere, the resort is close to bustling Duval Street. Explore the lively nightlife and local attractions, then retreat back to your peaceful sanctuary afterward.
Ocean Key Resort & Spa combines relaxation and excitement perfectly in the heart of Key West.
Address: 0 Duval St, Key West, FL 33040, United States
9. Hawks Cay Resort

Hawks Cay Resort in Duck Key offers a family-friendly getaway in the Florida Keys. You’ll find a wealth of activities here, from water sports to swimming pools and a marina. Engage in kayaking, fishing, or just unwind by the pool with the family.
The resort features beautifully designed rooms with modern amenities. Each room ensures comfort and relaxation for every guest. Gather the family for unforgettable memories filled with sunshine and laughter.
Dining at Hawks Cay highlights local flavors and ingredients. Enjoy casual meals by the pool or dine at a more upscale restaurant for a memorable evening. There’s something for every palate!
Take a break from routine with wellness activities and spa services available at the resort. Whether it’s yoga or simply relaxing, you’ll find the perfect space to rejuvenate.
Hawks Cay Resort enchants families with its extensive offerings and beautiful surroundings. Create cherished family memories in a picturesque paradise!
Address: 61 Hawks Cay Blvd, Duck Key, FL 33050, United States
10. Islander Watersports Resort

Islander Watersports Resort is the perfect destination for adventure enthusiasts. Located in Islamorada, this resort offers direct beach access and a range of exciting water sports. Dive into snorkeling, fishing, or jet skiing during your stay!
The accommodations provide comfort and lovely views. Wake up to the sound of waves and the beautiful sight of palm trees swaying in the breeze. It’s an idyllic setting to relax and recharge.
The resort’s location makes it easy to explore the surrounding islands. You can easily reach nearby attractions, shops, and restaurants for delicious meals and local experiences.
After a day full of adventure, unwind by the beach or at the pool. Sit back and enjoy the stunning sunset with a refreshing drink in hand.
Islander Watersports Resort creates an unforgettable experience for those who love fun and excitement in a beautiful tropical setting!
Address: 84600 Overseas Hwy, Islamorada, FL 33036, United States
11. Cheeca Lodge & Spa

Cheeca Lodge & Spa is a luxury destination in the heart of Islamorada. This resort combines natural beauty with modern comfort, offering a private beach and a full-service spa. It’s a perfect sanctuary for relaxation and rejuvenation.
The accommodations are nothing short of spectacular, styled with elegant decor and luxury amenities. The breathtaking views from your room will inspire you to venture out into the sun.
Indulge in delicious dining options featuring fresh seafood and gourmet dishes. Enjoy a casual meal by the beach or a fine dining experience with amazing flavors and presentation.
Engage in various resort activities such as water sports, fishing, or playing golf on-site. Explore the nearby islands and dive into the vibrant culture of the Florida Keys.
Cheeca Lodge & Spa is the ultimate getaway that captures the essence of luxury, fun, and relaxation in a tropical paradise.
Address: 81801 Overseas Hwy, Islamorada, FL 33036, United States
12. Lands End Resort
Lands End Resort in Big Pine Key offers a serene getaway for those seeking peace and tranquility. The charming resort has comfortable accommodations and easy access to nature trails and kayaking. The natural surroundings are perfect for birdwatching and wildlife spotting.
The rooms provide a cozy retreat after a long day of exploration. Enjoy the simplicity and beauty of island life while settling in.
Take advantage of the several outdoor activities available. Rent a kayak and explore the mangroves, or relax on the beach and enjoy the sun.
Dining options nearby feature local flavors and fresh seafood. Enjoy a laid-back meal at a local eatery, allowing you to savor the taste of the Keys.
Experience peace and quiet at Lands End Resort, where nature is your neighbor and relaxation comes naturally.
Address: 77567 Overseas Hwy, Big Pine Key, FL 33043, United States
13. Bungalows Key Largo

Bungalows Key Largo is an all-inclusive resort offering amazing experiences in luxury. Set in a breathtaking waterfront property, it features private bungalows, perfect for couples and families. Relax in your bungalow while enjoying stunning sunset views.
Delight in an all-inclusive experience, featuring dining, drinks, and activities. Explore the beach or participate in water sports, ensuring an exciting day awaits you.
Indulge in culinary delights that showcase local flavors without ever leaving the property. Try fresh seafood while soaking in the beauty around you.
Take advantage of spa services that pamper and relax. A serene atmosphere enhances your experience, making it feel like a true getaway.
Bungalows Key Largo is a luxurious resort that emphasizes relaxation while offering endless adventure opportunities.
Address: 1 Bungalows Key Largo, Key Largo, FL 33037, United States
14. Key Largo Bay Marriott Beach Resort
Key Largo Bay Marriott Beach Resort is perfect for families looking to enjoy a beautiful beach location. The resort features spacious rooms with modern amenities and stunning views of the bay. Easy access to the beach makes it ideal for water activities.
The resort boasts a private beach, multiple pools, and a marina, ensuring fun for everyone. Spend the day water skiing, paddle boarding, or simply relaxing on the sand.
Dining options on-site offer a taste of local cuisine. Each meal brings fresh flavors and delightful presentations, suitable for every palate.
With a warm and inviting atmosphere, the resort is designed for family bonding and fun. Tenants are greeted by friendly staff who accommodate your every need.
Key Largo Bay Marriott Beach Resort creates lasting family memories while providing a beautiful setting in the Florida Keys.
Address: 103800 Overseas Hwy, Key Largo, FL 33037, United States
15. Parmer’s Resort
Parmer’s Resort in Little Torch Key offers a quaint and relaxed island vibe. The charming cottages provide a unique stay, surrounded by beautiful gardens and a peaceful atmosphere. Enjoy your morning coffee on your porch with lovely views of the surroundings.
Engage in various activities like fishing, snorkeling, or simply basking in the sun. The private beach invites guests to relax and enjoy the gentle sea breeze.
Dining options nearby feature local eateries that showcase the flavors of the Keys. Try freshly caught fish in small family restaurants for a true taste of island life.
After a day of exploring, unwind in the spacious courtyard or around the fire pit with fellow guests. It’s a perfect way to end your day and create shared memories.
Parmer’s Resort caters to couples and small groups, offering intimate hospitality that makes you feel right at home.
Address: 16965 Overseas Hwy, Little Torch Key, FL 33042, United States
16. Edgewater Lodge

Edgewater Lodge is a waterfront paradise in Islamorada. This charming lodging offers comfortable accommodations and opportunities for fishing and water sports. You’ll love the laid-back atmosphere and friendly staff.
Relax by the water and soak up the sun. Take advantage of the lodge’s boat ramp for easy access to the surrounding waters. Adventure awaits whether you’re into scuba diving or paddleboarding!
The beaches are tranquil, inviting you to enjoy quiet moments under palm trees. Gather with friends and family for a beachside picnic, or simply relax with your favorite book.
Dining options are plenty nearby with local flavors and seafood reflecting Key West’s culinary history. Savor delightful meals in a cozy atmosphere that highlights true island life.
Edgewater Lodge is a great choice for an unforgettable getaway near the water.
Address: 104220 Overseas Hwy, Islamorada, FL 33036, United States
17. Pelican Cove Resort & Marina
Pelican Cove Resort & Marina is a vibrant beachfront retreat in Islamorada. Offering splendid views and access to water sports, this resort is perfect for families and friends looking for adventure. Dive into snorkeling or take a stroll along the beach.
The inviting accommodations provide all the comforts of home while ensuring a relaxing experience. Enjoy the tropical decor and warm hospitality during your stay.
Dine on-site to taste local flavors and fresh seafood. The open-air restaurant offers a delightful atmosphere with stunning views of the sunset over the water.
Take advantage of the resort’s amenities, including a pool and beach bar. Wind down after a long day of activity, sipping cocktails in the evening breeze.
Pelican Cove is where fun and relaxation come together for a memorable vacation in the Florida Keys.
Address: 84457 Overseas Hwy, Islamorada, FL 33036, United States
Final Thoughts
The Florida Keys is a spectacular destination that offers the perfect blend of adventure, relaxation, and unforgettable dining experiences. Each hotel presents its unique charm and amenities, meeting the desires of every traveler. Whether you prefer a luxurious beachfront resort or a cozy boutique hotel, the Keys has something special to offer.
As you explore the islands, you will encounter stunning landscapes, warm host communities, and incredible activities to participate in. For instance, discover the essential things to do in the Lower Keys or experience the delightful activities waiting for you in Key Biscayne with our guide on things to do in Key Biscayne. Indulging in local flavors and fresh seafood further adds to the flavor of your journey.